The anti-aging movement got its initial boost after the publication in 1990 in the New England Journal of Medicine of an article by Daniel Rudman, MD, professor of medicine and academic endocrinologist, whose career focused on the aging of the endocrine system and the resulting hormone deficiencies. His landmark article, "Effects of Human Growth Hormone in Men Over 60 Years Old", concluded that "Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occur in old age." (N Engl J Med 1990; 323:1-6.)
Us "anti-aging" or preventive medicine doctors rely on the increasing scientific evidence that optimizing hormones creates physical well-being. We see prevention of continued decline and even restoration of lost function. Conventional medicine, however, refuses to accept this simple concept.
Mainstream medicine is stuck on the idea that pharmaceuticals are the best answer to life’s woes as we strike middle age. Increasingly alien molecules, totally not found in nature, are somehow going to ease the diabetes, cardiovascular disease, high blood pressure, and other maladies that strike us later in life.
I have a patient who was doing very well on my bio-identical hormone program, who needed to see me, but could not due to distance. His new "provider" asked him why he was taking thyroid. He answered, for age-related decline. She told him that thyroid function does not go down with age.
Let’s look at the scientific literature.
“Serum TSH concentrations decrease in healthy elderly subjects due to an age-related decrease in TSH secretion by the pituitary.”[1,2,3] So, pituitary gland function declines with age, including production of the hormone (TSH) that stimulates the thyroid to produce more of what the thyroid gland makes, T4. The T4 is inactive, acting as an available store, and accessible for conversion throughout the body into the active form, T3. But, this T4 to T3 conversion occurs less and less efficiently as we age, also.
“After exclusion of.... confounders, most studies show similar results: A clear, age-dependent decline in serum Thyroid Stimulating Hormone (TSH) and (free) T3 ....” In the elderly, “Thyroid hormones levels are usually within the lower part of normal values reported in the general population.” “There is evidence that the decreased thyroid hormone levels observed in aging are due to lower TSH concentrations, and that lower TSH concentrations may be linked to an impaired pituitary activity.” But, as mentioned in the previous paragraph, T4 to T3 conversion is vital as well, with “the net result of this decreased de-iodination with advancing age is a clear, age-dependent decline in total and free T3 levels...”
Bottom line, in most humans, thyroid function declines with age. Exceedingly long-lived individuals do not show a decline of thyroid function.
Regarding the management of chronic health conditions, the sad reality about the current medical system is this: You get processed, but no benefit. In return for allowing the clinic to update your electronic medical record, and get access to your insurance money, you get a few prescriptions for pharmaceuticals that “manage” your problem. Who is satisfied with all this: the “provider’s” employer, who ends up with liability coverage and profit.
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